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四周疗程的大剂量甲基强的松龙治疗,可使严重的急性酒精性肝炎患者病势趋于稳定,渡过危险期而重获生机。 费城Jefferson医学院内科学教授Maddrey说,严重的酒精性肝炎患者接受短期口服甲基强的松龙(32mg/日)治疗,可以避免在急性期死亡。 Maddrey医师报告了用甲基强的松龙治疗和安慰剂对照的随机双盲研究。该研究是同时分别在Jefferson医学院、约翰霍普金斯大学、弗吉尼亚医学院及得克萨斯州大学进行的。
Treatment of high-dose methylprednisolone around the course of treatment can make patients with severe acute alcoholic hepatitis tend to be stable, over the dangerous period and regained vitality. Maddrey, an insider professor of medicine at Jefferson College of Medicine in Philadelphia, said patients with severe alcoholic hepatitis received short-term oral methylprednisolone (32 mg / day) treatment to avoid death in the acute phase. Maddrey reported randomized, double-blind studies comparing methylprednisolone and placebo. The study was conducted simultaneously at Jefferson Medical School, Johns Hopkins University, Virginia Medical College and the University of Texas.