论文部分内容阅读
目的:研究p15蛋白在骨肉瘤中的表达,探讨其表达与骨肉瘤的相关性。方法:采用S-P免疫组化方法,检测22例骨肉瘤中p15的表达;结果:p15蛋白在22例骨肉瘤中表达的阳性率为54.5％,而20例骨软骨瘤中阳性率为15.0％。骨肉瘤p15蛋白表达与骨软骨瘤相比差异具有统计学意义(x2=7.13,P<0.01)。结论:p15蛋白的表达与肿瘤的恶性度相关,与骨肉瘤的发生、发展具有相关性。
Objective: To study the expression of p15 protein in osteosarcoma and to explore its correlation with osteosarcoma. Methods: The expression of p15 in 22 cases of osteosarcoma was detected by S-P immunohistochemistry. Results: The positive rate of p15 protein was 54.5% in 22 cases of osteosarcoma and 15.0% in 20 cases of osteochondroma. Osteosarcoma p15 protein expression compared with osteochondroma was statistically significant (x2 = 7.13, P <0.01). Conclusion: The expression of p15 protein is correlated with the malignant degree of the tumor and is related with the occurrence and development of osteosarcoma.