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目的:探讨血清雌激素水平的变化与绝经后骨质疏松妇女血清骨硬化蛋白含量之间的关系。方法:比较分析100例健康妇女和100例绝经后骨质疏松妇女血清SO和E2水平的变化特点及相关性。结果:PMOP组血清E2水平显著下降(P<0.01),sost基因的mRNA水平和蛋白水平则明显上调(P<0.05),两者之间呈负相关(r=-0.57)。结论:PMOP患者存在sost基因表达显著上调的现象,该变化可能是由E2水平下降所至。
Objective: To investigate the relationship between serum estrogen levels and serum levels of sclerostin in postmenopausal women with osteoporosis. Methods: A comparative analysis of 100 healthy women and 100 cases of postmenopausal women with osteoporosis serum SO and E2 levels of changes in the characteristics and correlation. Results: Serum E2 level was significantly decreased in PMOP group (P <0.01). The mRNA and protein levels of sost gene were significantly increased (P <0.05), and negative correlation was found between them (r = -0.57). CONCLUSIONS: There is a significant up-regulation of sost gene expression in PMOP patients, which may be due to the decrease of E2 level.