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目的:探讨扶正化瘀方加味联合内分泌疗法治疗晚期前列腺癌的临床疗效。方法:将59例晚期前列腺癌患者随机分为治疗组29例和对照组30例。两组均采用前列腺癌的内分泌治疗方法,治疗组加用扶正化瘀方加味,治疗3个月后观察两组疗效。结果:两组治疗后生活质量评分均明显改善(P<0.05),且治疗组生活质量优于对照组(P<0.05);治疗组PSA、f-PSA改善,与治疗前比较差异均有统计学意义(P<0.05),且优于对照组(P<0.05,P<0.01);治疗组CD3+、CD4+、CD8+、CD4+/CD8+细胞水平改善,与治疗前比较差异均有统计学意义(P<0.05),且优于对照组(P<0.01);治疗组药物相关不良反应发生率优于对照组(P<0.05)。结论:扶正化瘀方加味联合内分泌疗法治疗能明显改善晚期前列腺癌患者生活质量,提高免疫功能,增强内分泌治疗作用,减少内分泌治疗的不良反应。
Objective: To investigate the clinical effects of Fuzheng Huayu recipe combined with endocrine therapy in the treatment of advanced prostate cancer. Methods: Fifty-nine patients with advanced prostate cancer were randomly divided into treatment group (n = 29) and control group (n = 30). Both groups adopted the method of endocrine treatment of prostate cancer. The treatment group was treated with Fuzhenghuayu recipe, and the curative effect was observed after 3 months of treatment. Results: The quality of life scores of both groups were significantly improved after treatment (P <0.05), and the quality of life of the treatment group was better than that of the control group (P <0.05). The PSA and f-PSA of the treatment group improved, (P <0.05), and better than the control group (P <0.05, P <0.01). The levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + cells in the treatment group were significantly improved <0.05), and better than the control group (P <0.01). The incidence of drug-related adverse reactions in the treatment group was better than that in the control group (P <0.05). Conclusion: Fuzhenghuayu decoction combined with endocrine therapy can significantly improve the quality of life of patients with advanced prostate cancer, improve immune function, enhance the role of endocrine therapy and reduce the adverse effects of endocrine therapy.