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目的比较同步放化疗与同步放化疗联合诱导化疗治疗局部晚期非小细胞肺癌的临床疗效。方法随机将120例患者分为对照组(60例)与观察组(60例),观察组患者采取诱导化疗联合同步放化疗治疗,对照组患者采取同步放化疗治疗,观察两组患者的临床疗效、总生存率及不良反应。结果两组患者的近期总有效率、总生存率和恶心、呕吐症状等差异均无统计学意义(均P>0.05);观察组患者白细胞在3~4级水平反而高于对照组(P<0.05);观察组患者血小板在2级水平高于对照组(P<0.05);观察组患者放射性肺炎症状高于对照组(P<0.05)。结论在提高临床疗效方面,观察组与对照组比较差异无统计学意义;而在不良反应方面,观察组患者高于对照组。
Objective To compare the clinical efficacy of concurrent chemoradiotherapy with concurrent chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer. Methods 120 patients were randomly divided into control group (60 cases) and observation group (60 cases). Patients in observation group were treated with induction chemotherapy combined with concurrent radiotherapy and chemotherapy while patients in control group were treated with concurrent chemoradiotherapy. The clinical efficacy , Overall survival and adverse reactions. Results There were no significant differences in the recent total effective rate, overall survival, nausea and vomiting between the two groups (all P> 0.05). The leukocytes in the observation group were higher than those in the control group on the 3rd to 4th levels (P < 0.05). The level of platelet in observation group was higher than that in control group (P <0.05). The symptoms of radiation pneumonitis in observation group were higher than those in control group (P <0.05). Conclusion There is no significant difference between the observation group and the control group in improving the clinical curative effect; while in the adverse reaction group, the observation group is higher than the control group.