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目的：探究糖尿病肾病蛋白尿患者采用前列地尔联合贝那普利的临床效果。方法选取本院2015年4月~2016年5月收治的68例糖尿病肾病患者，抽签分为2组，对照组实施常规治疗，观察组实施前列地尔联合贝那普利治疗。并对两组患者的24h 尿蛋白含量、尿微量白蛋白排泄率、不良反应发生率进行对比。结果治疗前两组患者24h 尿蛋白含量与尿微量白蛋白排泄率的对比无显著性差异（P>0.05）；两组患者治疗24h 尿蛋白含量与尿微量白蛋白排泄率均有所下降，且观察组的降低程度优于对照组（P0.05）。结论糖尿病肾病蛋白尿患者采用前列地尔联合贝那普利治疗，可使患者的治疗效果显著提高。“,”Objective To explore the clinical effect of patients with diabetic nephropathy proteinuria by alprostadil combined with Benner Pury. 68 cases of patients with diabetic nephropathy methods in our hospital from April 2015 ~2016 year in May, divided into 2 groups, the control group received routine treatment, the observation group received alprostadil combined with Benner Pury therapy. And 24h urine protein content of two groups patients, urinary albumin excretion rate, the incidence of adverse reactions were compared. The results of the two groups before treatment 24h urinary protein and urinary albumin excretion rate had no statistical y significant difference between the two groups (P>0.05); 24h treatment The content of urinary protein and urinary albumin excretion rate decreased, and the observation group decreased than the control group (P0.05). Conclusion the proteinuria of diabetic nephropathy treated with Alprostadil Combined with benazepril, the patients with remarkable curative effect to improve.