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目的探讨头孢呋辛钠在Beagle犬体内的毒代动力学,为临床用药提供参考。方法选取Beagle犬7只,随机分为阴性对照组和注射用头孢呋辛钠(1.65 g/kg)组,以静脉滴注方式给药。血浆样品采用反相高效液相色谱法测定头孢呋辛浓度,用DAS计算毒代动力学参数。结果头孢呋辛钠在Beagle犬体内的毒代动力学主要参数为:血浆药时曲线下面积(AUC0-t)为(4 745±1 607)mg(L·h),峰浓度(Cmax)为(2520±407)mg/L,平均滞留时间(MRT0-t)为(1.8±0.3)h,清除率(CL)为(0.38±0.16)L(h/kg),分布容积(Vd)为(0.56±0.15)L/kg。结论头孢呋辛在Beagle犬体内消除较快,基本分布于血浆,提示应无明显毒性蓄积。
Objective To investigate the toxicokinetics of cefuroxime sodium in Beagle dogs and provide reference for clinical use. Methods Seven Beagle dogs were randomly divided into negative control group and cefuroxime sodium for injection (1.65 g / kg), and were given intravenously. Plasma samples were analyzed for cefuroxime density using reversed-phase high-performance liquid chromatography and toxicokinetic parameters were calculated using DAS. Results The main parameters of toxicokinetics of cefuroxime sodium in Beagle dogs were as follows: the area under the curve of plasma drug concentration (AUC0-t) was (4745 ± 1 607) mg (L · h) and the peak concentration (2520 ± 407) mg / L, mean retention time (MRT0-t) was 1.8 ± 0.3 h, clearance rate was 0.38 ± 0.16 L / h and Vd was 0.56 ± 0.15) L / kg. Conclusion Cefuroxime rapidly disappeared in Beagle dogs and distributed mainly in the plasma, suggesting no obvious toxicity accumulation.