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A biodegradable tumor targeting nano-probe based on poly(ε-caprolactone)-b-poly(ethylene glycol)block copolymer(PCL-b-PEG)micelle functionalized with a magnetic resonance imaging(MRI)contrast agent diethylenetriaminepentaacetic acid-gadolinium(DTPA-Gd~(3+))on the shell and a near-infrared(NIR)dye in the core for magnetic resonance and optical dual-modality imaging was prepared.The longitudinal relaxivity(r_1)of the PCL-b-PEG-DTPA -Gd~(3+)micelle was 13.4(mmol/L)~(-1)s~(-1),three folds of that of DTPA-Gd~(3+),and higher than that of many polymeric contrast agents with similar structures.The in vivo optical imaging of a nude mouse bearing xenografted breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention(EPR)effect.The results indicated that the dualmodality micelle is a promising nano-probe for cancer detection and diagnosis.
A biodegradable tumor targeting nano-probe based on poly (ε-caprolactone) -b-poly (ethylene glycol) block copolymer (PCL-b-PEG) micelle functionalized with a magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid-gadolinium -Gd ~ (3 +)) on the shell and a near-infrared (NIR) dye in the core for magnetic resonance and optical dual-modality imaging was prepared. Longitudinal relaxivity (r_1) of the PCL-b-PEG- DTPA Gd ~ (3 +) micelle was 13.4 (mmol / L) ~ (-1), three folds of that of DTPA-Gd ~ (3 +), and higher than that of many polymeric contrast agents with similar structures. in vivo optical imaging of a nude mouse bearing xenografted breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention (EPR) effect. The results indicated that the dualmodality micelle is a promising nano-probe for cancer detection and diagnosis.