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报道 2 庚基 5 (N ,N 二取代胺甲基 ) 2 环戊烯酮 (Ⅰ1)～ (Ⅰ4 )和 2 戊基 5 (N ,N 二取代胺甲基 ) 2 环戊烯酮 (Ⅱ1)～ (Ⅱ3 )的设计和合成 ,它们均属于 2 烷基 2 环戊烯酮 1的Mannich碱盐酸盐类化合物 .以环戊酮为起始原料 ,经Aldol缩合、双键转位和Mannich反应 ,合成了 7个目标化合物 ,其中 6个未见文献报道 ,其结构均经红外光谱、核磁共振氢谱和元素分析等数据证实 ,同时进行体外和体内抗癌活性筛选 .
It is reported that 2-heptyl 5 (N, N-disubstituted aminomethyl) 2cyclopentenone (II) to (I4) and 2pentyl 5 (N, N-disubstituted aminomethyl) ~ (Ⅱ3) were designed and synthesized, which belong to Mannich base hydrochloride of 2-alkyl 2-cyclopentenone 1. Starting from cyclopentanone, Aldol condensation, double bond translocation and Mannich reaction, Seven target compounds were synthesized, of which six were not reported in the literature. Their structures were confirmed by IR, 1HNMR and elemental analysis. The anti-cancer activities were also screened in vitro and in vivo.