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目的研究巨噬细胞移动抑制因子(MIF)基因-173G>C多态性与江苏人群宫颈癌遗传易感性的关系。方法采用PCR-限制性片段长度多态性技术检测MIF-173G>C多态性在455例宫颈癌患者和447例年龄相匹配正常对照者的频率和分布。比较不同基因型携带者患宫颈癌的危险性;通过分层分析探讨年龄、初潮年龄、初次生育年龄、产次、流产数及绝经状态对罹患宫颈癌的影响。结果病例组和对照组间MIF-173G>C各基因型频率差异无统计学意义(P>0.05)。分层分析结果显示,在不同年龄、初潮年龄、初次生育年龄、产次、流产数及是否绝经特征分层中,病例组与对照组各基因型频率差异仍无统计学意义。结论本研究未发现MIF-173G>C多态性与江苏人群宫颈癌的发生存在统计学关联。
Objective To study the relationship between the -173G> C polymorphism of macrophage migration inhibitory factor (MIF) gene and genetic susceptibility to cervical cancer in Jiangsu population. Methods The frequency and distribution of MIF-173G> C polymorphism in 455 cases of cervical cancer and 447 age-matched normal controls were detected by PCR-restriction fragment length polymorphism. To compare the risk of cervical cancer among carriers of different genotypes; to investigate the influence of age, menarche age, first childbearing age, parity, abortion number and menopausal status on cervical cancer by stratified analysis. Results There was no significant difference in the frequencies of MIF-173G> C between case group and control group (P> 0.05). Stratified analysis showed that in different age groups, age at first menarche, first childbearing age, parity, abortion number and whether the stratification of menopause, there was no significant difference in genotype frequencies between case group and control group. Conclusions This study found no statistical association between the MIF-173G> C polymorphism and the occurrence of cervical cancer in Jiangsu population.