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树突状细胞（ DC）在诱导和调节免疫反应中起关键作用，包括激活消除肿瘤细胞的细胞毒性T淋巴细胞。以DC为基础的肿瘤疫苗能够被机体耐受、很少有不良反应，同时又能诱导抗肿瘤的免疫反应，但是其效果有限。研究表明，DC具有多种表型，CD141＋DC 在抗肿瘤反应中扮演着重要的角色。这成为DC疫苗在体内应用发展的新方向。对不同 DC 亚群特殊功能的深入了解，以及对肿瘤抗原负载新方法的研究，为设计出更有效的DC肿瘤疫苗指出了一条更有希望的道路。“,”Dendritic cells(DC) play a key role in the induction and regulation of immune responses, including the activation of cytotoxic T lymphocytes for the eradication of cancers .DC-based cancer vaccines can be tolerated,with few side effects and can induce anti-tumor immune responses,but the overall effects are limited.Recent studies showed that CD141 +DC play an important role in anti-tumor responses.These are now novel targets for the development of vaccines that directly target DC in vivo .With the deepening of the under-standing of the specialized functions of DC subsets,strategies for the delivery of tumor Ag to DC,a promising new direction for the design of more effective DC-based cancer vaccines is pointed out.