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长期以来血浆总T_4与TSH测定用于监测甲低患儿的激素治疗,但它们的结果经常矛盾。以前对治疗的甲低患儿血浆总T_4和TSH值的研究,未发现两种激素水平间的相关性,或只发现弱相关(r=-0.23)。最近作者使用血浆游离T_4(f-T_4)一步RIA新方法来监测以及诊断甲状腺机能减退。 血浆f—T_4一步RIA新方法比间接法、两步法、修改的纸片法及其它RIA更为简易、快速。其最低可检出值0.8pmol/l;在可测定范围内T_4高浓度为4％,低浓度为9％,平均6％,血浆f-T_4值与经典的平衡透析法高度相关,Y=0.77-0.14,r=0.98.采血时间自上午9时至下午2时,
Long-term total plasma T 4 and TSH assays have been used to monitor hormone therapy in children with hypothyroidism, but their results often conflict. Previous studies of plasma total T 4 and TSH values in children with hypothyroidism did not reveal a correlation between the two hormone levels or only a weak correlation (r = -0.23). Recently, the authors used a plasma free T_4 (f-T_4) one-step RIA new method to monitor and diagnose hypothyroidism. The new method of plasma f-T_4 one-step RIA is more simple and rapid than indirect method, two-step method, modified sheet method and other RIA. The lowest detectable value of 0.8pmol / l; within the measurable range of T_4 high concentration of 4%, low concentration of 9%, an average of 6%, plasma f-T_4 value with the classic equilibrium dialysis was highly correlated, Y = 0.77 -0.14, r = 0.98. Blood sampling time from 9 am to 2 pm,