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0 引言 环氧合酶 2 (COX 2 )是催化花生四烯酸代谢为前列腺素 (PG)的限速酶 ,参与炎症、肿瘤等病理过程 .研究表明 ,许多肿瘤的发生、发展均与COX 2的表达有关 .血管内皮生长因子 (VEGF)对血管内皮细胞增殖有直接作用 ,是最主要的促血管生长因子之一 ,在肿瘤的生长过程中发
0 Introduction Cyclooxygenase 2 (COX 2) is a rate-limiting enzyme that catalyzes the metabolism of arachidonic acid to prostaglandins (PGs) and is involved in pathological processes such as inflammation and oncology. Studies have shown that many tumors are associated with the development and progression of COX 2 Of vascular endothelial growth factor (VEGF) has a direct effect on the proliferation of vascular endothelial cells, is one of the most important pro-angiogenic growth factor in the growth of the tumor