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对染色体易位相关软组织肉瘤(chromosomal translocation-associated sarcomas,CTASs)与染色体易位非相关软组织肉瘤(chromosomal translocation-nonassociated sarcomas,CTNASs)在临床病理组织学和免疫组织化学方面的不同特点进行初步观察和比较。回顾性分析108例CTASs与CTNASs的临床病理组织与细胞形态学特点,同时采用免疫组织化学Envision法检测EGFR、HER-2、CD117、P53、MDM2蛋白的表达和分布。结果显示,本组108例软组织肉瘤中,CTASs患者发病年龄(平均约29.2岁)较CTNASs患者发病年龄(平均约44.7岁)小。形态学上,CTASs多以小圆形细胞为主型(53.8%)和梭形细胞为主型(46.2%)居多,而CTNASs则以多型性细胞为主(51.2%)。免疫组织化学染色显示,CTASs与CTNASs中P53、MDM2、HER-2、CD117、EGFR蛋白的阳性表达率分别为75.4%和72.1%、16.9%和41.9%、12.3%和9.3%、4.6%和0、23.1%和11.6%。经卡方检验,MDM2在CTASs与CTNASs中的表达差异有显著性,提示MDM2可能在CTNASs发病机制中扮演重要的角色。
Chromosomal translocation-associated sarcomas (CTASs) and chromosomal translocation-nonassociated sarcomas (CTNASs) in the clinicopathological and immunohistochemical characteristics of the initial observations and Compare The clinicopathological and cytomorphological features of 108 CTASs and CTNASs were retrospectively analyzed. The expression and distribution of EGFR, HER-2, CD117, P53 and MDM2 protein were detected by immunohistochemistry Envision method. The results showed that in this group of 108 cases of soft tissue sarcoma, CTASs patients with the age of onset (average 29.2 years old) than the CTNASs onset age (average 44.7 years old) smaller. Morphologically, most CTASs were predominantly small round cells (53.8%) and spindle cells predominant (46.2%), whereas CTNASs were mostly polymorphic (51.2%). Immunohistochemical staining showed that the positive rates of P53, MDM2, HER-2, CD117 and EGFR in CTASs and CTNASs were 75.4% and 72.1%, 16.9% and 41.9%, 12.3% and 9.3%, 4.6% and 0 , 23.1% and 11.6% respectively. By chi-square test, the expression of MDM2 in CTASs and CTNASs was significantly different, suggesting that MDM2 may play an important role in the pathogenesis of CTNASs.