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目的:通过研究缬沙坦对急性心肌梗死(AMI)患者的细胞因子、肾素血管紧张素系统(RAS)和心脏功能影响,探讨干预心室重塑的免疫调节机制。方法:已确诊AMI患者被随机分为2组:缬沙坦组(40例)和对照组(39例)。血管紧张素Ⅱ(AngⅡ)和醛固酮及肾素活性(PRA)采用放射免疫法检测。血清细胞因子检测采用双抗体夹心ELISA法,并用超声检测同期心脏功能。结果:与对照组比较,缬沙坦组治疗7d后高敏C反应蛋白、肿瘤坏死因子-α、转化生长因子β1明显下降,白细胞介素-10上升;血浆PRA和醛固酮减少和AngII上升;左室射血分数提高,差异均有统计学意义(P<0.05)。结论:缬沙坦调节AMI患者的细胞因子和RAS,改善心脏功能,具有免疫调节和防治心室重塑的作用。
OBJECTIVE: To investigate the effects of valsartan on cytokines, renin-angiotensin system (RAS) and cardiac function in patients with acute myocardial infarction (AMI) and to explore the mechanism of intervention in the regulation of ventricular remodeling. Methods: AMI patients were randomly divided into 2 groups: valsartan group (40 cases) and control group (39 cases). Angiotensin Ⅱ (AngⅡ) and aldosterone and renin activity (PRA) were detected by radioimmunoassay. Serum cytokine detection using double antibody sandwich ELISA, and simultaneous detection of cardiac function with ultrasound. Results: Compared with the control group, the levels of high-sensitivity C-reactive protein, tumor necrosis factor-α and transforming growth factor-β1 were significantly decreased, interleukin-10 increased, plasma PRA and aldosterone decreased, The ejection fraction increased, the differences were statistically significant (P <0.05). Conclusion: Valsartan regulates cytokines and RAS in patients with AMI, improves cardiac function, and has immunomodulatory effects and prevention and treatment of ventricular remodeling.