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来曲唑是第三代芳香化酶抑制剂,主要用于绝经期乳腺癌的治疗。近年研究表明:来曲唑可有效用于促排卵。来曲唑半衰期短,通过外周和中枢两方面发挥促排卵作用,无类似氯米酚的抗雌激素作用,促排卵效果好,对宫颈黏液、子宫内膜和性激素水平影响小。可用于对氯米酚抵抗和多囊卵巢综合征患者的促排卵治疗,作为体外受精-胚胎移植的辅助用药,可改善卵巢低反应患者的助孕结局,减少促性腺激素用量,降低治疗费用,亦可用于恶性肿瘤患者促排卵,对胎儿无明显致畸作用。可能成为新一代一线促排卵药物。
Letrozole is the third generation of aromatase inhibitors, mainly used in the treatment of menopausal breast cancer. In recent years, studies have shown that: Letrozole can be effectively used to promote ovulation. Letrozole has a short half-life and exerts the effect of promoting ovulation both in the peripheral and the central. There is no anti-estrogen effect similar to that of chlorpheniramine and the effect of promoting ovulation is good. The effect of letrozole on cervical mucus, endometrium and sex hormone is small. Can be used for ovicidally treating patients with clomiphene resistance and polycystic ovary syndrome, and as an auxiliary treatment of in vitro fertilization and embryo transfer, can improve the pregnancy-assisted outcome of patients with ovarian low response, reduce the dosage of gonadotropin, reduce the treatment cost, Ovulation can also be used for patients with malignant tumors, no significant teratogenic effects on the fetus. May become a new generation of first-line ovulation drugs.