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目的探讨三酰甘油与高密度脂蛋白胆固醇比值(TG/HDL-C)与绝经后女性代谢综合征(MS)的相关性。方法选取2013年8—12月在新疆医科大学第一附属医院体检中心进行健康体检的绝经后女性(≥50岁)408例为研究对象,按照2005年国际糖尿病联盟(IDF)标准将绝经后女性分为MS组和非MS组。检测两组血脂水平,计算TG/HDL-C,数据分析采用SPSS 17.0统计软件完成。结果 MS组与非MS组TG/HDL-C〔(1.70±0.77)比(0.74±0.46)〕比较,差异有统计学意义(P<0.05)。根据TG/HDL-C水平的四分位数分组,随着TG/HDL-C水平的增高,各组间体质指数(BMI)、收缩压、空腹血糖、TG逐渐升高,高密度脂蛋白胆固醇(HDL-C)逐渐降低,差异有统计学意义(P<0.05)。人工受试者工作特征(ROC)曲线分析当TG/HDL-C切值取0.903时,对MS的诊断效率最高,曲线下面积为0.882〔P=0.000,95%CI(0.844,0.920)〕,灵敏度为87.40%、特异度为74.40%。结论 TG/HDL-C可能是绝经后女性MS良好的诊断指标。
Objective To investigate the relationship between triglyceride and high density lipoprotein cholesterol (TG / HDL-C) and metabolic syndrome (MS) in postmenopausal women. METHODS: A total of 408 postmenopausal women (≥50 years old) undergoing physical examination in the First Affiliated Hospital of the First Affiliated Hospital of Xinjiang Medical University from August 2013 to December 2013 were enrolled in this study. According to the 2005 International Union of Diabetes (IDF) criteria, postmenopausal women Divided into MS group and non-MS group. Blood lipid levels were measured to calculate TG / HDL-C, data analysis using SPSS 17.0 statistical software. Results The difference of TG / HDL-C (1.70 ± 0.77) (0.74 ± 0.46) between MS group and non-MS group was statistically significant (P <0.05). According to the quartiles of TG / HDL-C level, BMI, systolic blood pressure, fasting blood glucose and triglyceride gradually increased with the increase of TG / HDL-C levels. The levels of high density lipoprotein cholesterol (HDL-C) gradually decreased, the difference was statistically significant (P <0.05). ROC Curve Analysis When the cut-off value for TG / HDL-C was 0.903, the diagnostic efficiency was highest for MS, with an area under the curve of 0.882 (P = 0.000, 95% CI, 0.844, 0.920) The sensitivity was 87.40% and the specificity was 74.40%. Conclusion TG / HDL-C may be a good diagnostic marker for MS in postmenopausal women.