论文部分内容阅读
荧光素钠滴眼液用于诊断角膜表层损伤,不是常用的治疗用药,因此,配制一批,用的时间较长,在配制时除用高温灭菌外,还要添加适宜的抑菌剂,以防止药液在贮存中染菌生霉。本制剂的抑菌剂据文献报道大致有3类:有机汞化合物、尼泊金酯类、三氯叔丁醇,其中以选用三氯叔丁醇作抑菌剂的最多。笔者认为选用三氯叔丁醇不妥。三氯叔丁醇在高温或碱性溶液中均易分解而降低抑菌效能,同时水解生成的盐酸,使溶液的pH下降,当pH5～9时,在常温下存放6周后可损失10%,故只适宜作不通过加热和短时间用完的弱酸性溶液的抑
Fluorescein sodium eye drops for the diagnosis of corneal surface damage, is not commonly used for treatment, therefore, the preparation of a batch, with a longer time, in addition to the preparation of high temperature sterilization, but also add appropriate antibacterial agents, In order to prevent the liquid medicine in storage bacteria mold. The preparation of bacteriostatic agents reported in the literature there are roughly three categories: organic mercury compounds, paraben esters, chlorobutanol, of which the choice of chlorobutanol as a bacteriostatic agent up. I believe that the choice of chlorobutanol inappropriate. Chlorobutanol in the high temperature or alkaline solution are easy to decompose and reduce the bacteriostasis performance, while hydrolysis of hydrochloric acid, the pH of the solution decreased, when pH 5 ~ 9, at room temperature for 6 weeks after the loss of 10% , It is only suitable for the weak acid solution that does not pass the heating and short run out of time