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二、追溯求源法药物合成设计的基水课题是以何种化学物质作为起始原科,经过多少合成步骤,采用那些化学反应或合成方法以制成所需要的医药产品。而制订此种合成方案的极为有效方法之一,就是逆合成的追溯求源法或寻源思考法,又称倒推法。从靶分子的化学结构出发,将其合成过程一步一步地向前推导进行追溯求源,即首先从药物化学结构的最后一个结合点考虑其前驱物质是什么和用什么反应得到最终产物的;其次再从这个前驱物
Second, tracing the source method of drug synthesis design of the base water is based on what kind of chemical substances as the initial section, after how many synthetic steps, the use of those chemical reactions or synthetic methods to make the required medical products. One of the most effective methods of formulating this kind of synthesis scheme is reverse synthesis or retrospective source-seeking method, also known as back-push method. Starting from the chemical structure of the target molecule, the synthesis process is derived step by step from the origin of the retrospective search, that is, the last point of the chemical structure of the drug is to consider what the precursor is and what reaction to obtain the final product; From this precursor again