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目的观察热疗联合胸腔内注射化疗药物顺铂治疗肺癌恶性胸水的疗效、生活质量和不良反应。方法确诊为肺癌所致的恶性胸水患者60例,随机分为2组。2组患者均胸腔穿刺抽液或胸腔闭式引流排尽胸水,单纯化疗组(对照组)30例仅胸腔内注入顺铂60 mg;联合化疗组(观察组)30例胸腔内注入在水浴箱加热至43℃灭菌蒸馏水+顺铂60 mg。结果观察组(总有效率83.3%)疗效优于对照组(总有效率36.7%)(P<0.05);生活质量观察组改善率(83.3%)优于对照组(46.7%)(P<0.05);不良反应两组无显著性差异(P>0.05)。结论热疗联合胸腔内注射化疗药物治疗肺癌恶性胸水疗效确切,生活质量改善明显,具有一定临床意义。
Objective To observe the curative effect, quality of life and adverse reactions of hyperthermia combined with intrapleural chemotherapy with cisplatin in the treatment of malignant pleural effusion of lung cancer. Methods Sixty patients with malignant pleural effusion diagnosed as lung cancer were randomly divided into two groups. Thirty patients in both groups were treated by thoracentesis or pleural drainage by pleural effusion. In the chemotherapy group (control group), only 30 cases of cisplatin were injected intrathoracically in 30 patients in the control group. Thirty patients in the combination chemotherapy group (observation group) Heated to 43 ℃ sterilized distilled water + cisplatin 60 mg. Results The improvement rate of the observation group (83.3%) was better than that of the control group (36.7%) (P <0.05), and the improvement rate of the quality of life observation group (83.3%) was superior to that of the control group (46.7% ); Adverse reactions no significant difference between the two groups (P> 0.05). Conclusions The combination of hyperthermia and intrathoracic injection of chemotherapeutic drugs in the treatment of malignant pleural effusion of lung cancer has definite curative effect and significant improvement of quality of life, which is of clinical significance.