,Leukemia, an effective model for chemical biology and target therapy1

• 作 者: Guo-qiang CHEN Li-shun WANG Ying-li WU Yun YU
• 机 构: Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minis
• 出 处: 中国药理学报（英文版）
• 发表日期: 2007年9期
• 关键词: leukemia chemical biology target therapy retinoic acid arsenic trioxide differen

The rapid rise of chemical biology aimed at studying signaling networks for basic cellular activities using specific, active small molecules as probes has greatly accelerated research on pathological mechanisms and target therapy of diseases.This research is especially important for malignant tumors such as leukemia, a heterogeneous group of hematopoietic malignancies that occurs worldwide. With the use of a chemical approach combined with genetic manipulation, great progresshas been achieved over the past few decades on the biological, molecular and cytogenetic aspects of leukemia, and in its diagnosis and therapy. In particular,discoveries of the clinical effectiveness of all-trans rctinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia and the kinase inhibitorsImatinib and Dasatinib in the treatment of chronic myelogenous leukemia not only make target therapy of leukemia a reality, but also push mechanisms of leukemo-genesis and leukemic cell activities forward. This review will outline advances in chemical biology that help our understanding of the molecular mechanisms of cell differentiation and apoptosis induction and target therapy of leukemia.