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目的探讨染色体数目畸变与膀胱癌分期、分级及预后的关系。方法对２０例膀胱癌患者行外周血淋巴细胞染色体数目畸变进行分析。结果患者组中亚二倍体、超二倍体、多倍体的出现率及总畸变率均明显高于正常对照组（Ｐ＜００５）。结论随着肿瘤恶性程度的增加，染色体变异范围扩大，多倍体的出现可能预示着肿瘤的恶性倾向和患者的预后不佳
Objective To investigate the relationship between the number of chromosomal aberrations and the staging, grading and prognosis of bladder cancer. Methods 20 cases of bladder cancer patients with peripheral blood lymphocyte chromosome aberrations were analyzed. Results The sub-diploid, diploid, polyploidy and total aberration rates in patients were significantly higher than those in normal controls (P <005). Conclusion With the increase of the malignant degree of the tumor, the range of chromosomal aberrations is widened. The occurrence of polyploidy may indicate the malignant tendency of the tumor and the poor prognosis of the patient