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早在1893年就曾有继发于糖尿病性神经病水肿的描述,直到50年后Rundles氏等才认识到这种水肿是神经病的表现之一,然而其发生原因仍不详,而且难以治疗。 本文作者报告4例糖尿病性神经病水肿患者,经麻黄素治疗后(剂量为30～60mg/日)取得满意消肿效果。服药7天后,体重平均下降7.43±4.51kg。停药后,水肿再现,但再次服药后,仍然有效。持续服药观察12～15个月、4例患者均保持良好疗效。其中1例曾测24小时尿钠排出量,由治疗前177±5.20Mmol增至502±78Mmol。
As early as 1893, there was a description of edema secondary to diabetic neuropathy. It was not until Rundles et al. Recognized that this edema was one of the manifestations of neuropathy after 50 years. However, its cause is still unknown and difficult to treat. The authors report 4 patients with diabetic neuropathy edema, after ephedrine treatment (dose of 30 ~ 60mg / day) to obtain satisfactory swelling. After 7 days of medication, the average weight loss of 7.43 ± 4.51kg. After withdrawal, edema reappears, but after taking the drug again, still effective. Continuous medication observation of 12 to 15 months, 4 patients were maintained good effect. Among them, one case had a 24-hour urinary sodium excretion measured before treatment from 177 ± 5.20Mmol to 502 ± 78Mmol.