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临床资已经证实,某些子宫内膜癌呈雌激素依赖性,且孕激素治疗可致1/3的晚期或转移患者达到客观缓解.目前本病内分泌治疗的选择多以孕酮受体PR测定为依据,但由于其阳性率高达60～80%,故作为理想指标尚嫌不足.鉴于已有报告证实肌酸激酶(CK)在啮齿动物子宫内和人乳腺癌内是雌激素作用的一个非常敏感的标志,本文提出受体与CK联合测定的方法,并证实了该法有助于子宫内膜癌患者内分泌治疗的选择.本研究包括29例组织学证实的子宫内膜癌患者.所有患者均已自然绝经至少三年以上.病人首次刮宫术活检后,口服三苯氧胺(TAM),40mg/
Clinical evidence has confirmed that some endometrial cancer was estrogen-dependent, and progestin therapy can cause 1/3 of advanced or metastatic patients to achieve objective relief.At present, the choice of endocrine therapy of this disease with progesterone receptor PR assay , But it is not ideal as an ideal indicator since its positive rate is as high as 60-80% Given that it has been reported that creatine kinase (CK) is a very estrogenic factor in rodent utero and human breast cancer Sensitive markers, this paper presents a combination of receptor and CK determination of the method and confirmed that the method of endocrine therapy in patients with endometrial cancer treatment options .This study includes 29 cases of histologically confirmed endometrial cancer patients.All patients Have been naturally menopause for at least three years or more after the patient first curettage biopsy, oral tamoxifen (TAM), 40mg /