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目的:评价头孢替唑钠与炎琥宁联用对急性感染性心内膜炎患者的临床疗效及其对炎症因子水平的影响。方法:选取2014年11月—2017年2月间收治的急性感染性心内膜炎患者60例,将其随机分为单用组和联用组(每组30例);单用组患者给予头孢替唑钠治疗,联用组患者在单用组治疗基础上加用炎琥宁治疗,比较两组患者治疗后的总有效率和血沉(ESR)、血清降钙素(PCT)及超敏C反应蛋白(hs-CRP)等指标值的变化情况。结果:联用组患者治疗后总有效率明显高于单用组(P<0.05),用药期间不良反应的发生率低于单用组(P<0.05);治疗后联用组患者的ESR、PCT及hs-CRP等指标测得值低于单用组(P<0.05)。结论:头孢替唑钠与炎琥宁联用治疗急性感染性心内膜炎患者,其临床疗效较为显著,明显改善了炎症因子水平。
Objective: To evaluate the clinical efficacy of ceftezole sodium and mesylate in patients with acute infective endocarditis and its effect on the level of inflammatory cytokines. Methods: Sixty patients with acute infective endocarditis admitted between November 2014 and February 2017 were randomly divided into single and combined groups (30 in each group), patients in the single group Ceftezole sodium treatment, the combined group of patients in the single group therapy plus Yan Hu Ning treatment, the two groups were compared after treatment of total effective rate and ESR, serum calcitonin (PCT) and hypersensitivity C-reactive protein (hs-CRP) and other indicators of changes. Results: The total effective rate in the combined group was significantly higher than that in the single group (P <0.05). The incidence of adverse reactions in the combined group was lower than that in the single group (P <0.05) PCT and hs-CRP and other indicators measured value was lower than the single use group (P <0.05). Conclusion: Ceftezole sodium and mesylate combined treatment of acute infective endocarditis in patients with clinical efficacy was more significant, significantly improved the level of inflammatory cytokines.