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近年来代谢性疾病和抑郁症的发病率逐渐上升,临床研究表明代谢紊乱疾病与抑郁症之间存在共病现象。富含高糖高脂的西方饮食通常可造成肥胖、糖尿病、代谢综合征等代谢紊乱性疾病,近期研究发现高脂饮食是情绪障碍发病的危险因素,然而具体高脂饮食对情绪紊乱的影响机制尚未明确,其可能机制包括胰岛素抵抗、瘦素抵抗、炎症、氧化应激、神经凋亡、大脑奖赏回路系统等。本文对近年来报道的高脂饮食诱发情绪障碍可能机制及药物研究进行阐述。
In recent years, the incidence of metabolic diseases and depression gradually increased, clinical studies have shown that there is a co-morbidity between metabolic disorders and depression. Western diet rich in high-sugar and high-fat can often cause metabolic disorders such as obesity, diabetes and metabolic syndrome. Recent studies have found that high-fat diet is a risk factor for the development of emotional disorders. However, the mechanism of emotional disturbance caused by high-fat diet It is not yet clear, its possible mechanisms include insulin resistance, leptin resistance, inflammation, oxidative stress, neuronal apoptosis, brain reward loop system. This article describes the possible mechanism and drug research of emotional disorder induced by high fat diet reported in recent years.