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In the present paper,we overview the discovery of new biological activitiesinduced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action.Both compounds could increase neural plasticity in efficacy and structure;espe-cially Rg1,as one small molecular drug,can increase proliferation and differentia-tion of neural progenitor cells in dentate gyrus of hippocampus of normal adultmice and global ischemia model in gerbils.This finding has great value for treat-ment of Alzheimer’s disease and other neurodegenerative disorders which is char-acterized by neurons loss.Increase of expression of brain derived neurotrophicfactor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibitionof apoptosis and calcium overload are also important neuron protective factors.Rgl and Rbl have common effects,but there are some differences in pharmacol-ogy and mechanism.These differences may attribute to their different chemicalstructure.Rg1 is panaxtriol with two sugars,while Rb1 is panaxtriol with foursugars.
In the present paper, we overview the discovery of new biological activitiesinduced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action.Both things can increase neural plasticity in efficacy and structure;espe-cially Rg1,as one small molecular drug,can increase proliferation And differentia-tion of neural progenitor cells in dentate gyrus of hippocampus of normal adultmice and global ischemia model in gerbils.This finding has great value for treatment-ment of Alzheimer’s disease and other neurodegenerative disorders which is char-acterized by neurons loss.Increase of Expression of brain derived neurotrophic factor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibition of apoptosis and calcium overload are also important neuron protective factors.Rgl and Rbl have common effects,but there are some differences in pharmacol-ogy and mechanism.These Differences may attribute to their different chemicalstructure.Rg1 is panaxtriol with two sugars,while Rb1 is pan Axtriol with foursugars.