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目的 :制备复方环麻滴鼻凝胶剂及其质量控制。方法 :以卡波姆 94 0为乳化剂 ,三乙醇胺调节pH ,制备水溶性透明凝胶。用紫外分光光度法和旋光度法分别测定凝胶剂中盐酸环丙沙星和盐酸麻黄碱的含量。结果 :制备的凝胶均匀细腻 ,稠度适宜。盐酸环丙沙星的含量平均值为 10 2 .3% ,RSD为 1.86 % ;平均回收率为 99.4 % ,RSD为 0 .2 6 %。盐酸麻黄碱的平均含量为 10 3.7% ,RSD为 2 .8% ;平均回收率为99 .7% ,RSD为 0 .81%。结论 :该制剂性质稳定 ,无刺激性 ,测定方法简单易行 ,快速准确 ,适合医院制剂
OBJECTIVE: To prepare compound ginaton intranasal gel and its quality control. Methods: Carbopol 94 0 was used as emulsifier and triethanolamine was used to adjust the pH to prepare water-soluble transparent gel. The contents of ciprofloxacin hydrochloride and ephedrine hydrochloride in gel were determined by UV spectrophotometry and optical rotation method respectively. Results: The prepared gels were fine and fine, with suitable consistency. The average content of ciprofloxacin hydrochloride was 102.3% with a RSD of 1.86%. The average recovery was 99.4% with a RSD of 0.226%. The average content of ephedrine hydrochloride was 10 3.7% with a RSD of 2.8%. The average recovery was 99.7% with a RSD of 0.81%. Conclusion: The preparation is stable in nature and non-irritating. The method is simple, rapid and accurate, suitable for hospital preparations