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AIM:To find new serum biomarkers for liver cirrhosis (LC)in chronic carriers of hepatitis B virus (HBV).METHODS:Surface enhanced laser desorption/ionizationtime-of-flight (SELDI-TOF) mass spectrometry was usedto discover biomarkers for differentiating HBV induced LCfrom non-cirrhotic cohorts.A training population of 25 patientswith HBV-induced LC,20 patients with HCC,and 25 closelyage-matched healthy men,was studied.RESULTS:Two biomarkers with M_r 7 772 and 3 933 weredetected in sera of non-cirrhotic cohorts,but not in patientswith HBV-induced LC.A sensitivity of 80% for all LC patients,a specificity of 81.8% for all non-cirrhotic cohorts and apositive predictive value of 75% for the study populationwere obtained.CONCLUSION:These two serum biomarkers for HBV-induced LC might be used for diagnosis and assessment ofdisease progression.
AIM: To find new serum biomarkers for liver cirrhosis (LC) in chronic carriers of hepatitis B virus (HBV). METHODS: Surface enhanced laser desorption / ionizationtime-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating HBV induced LCfrom non-cirrhotic cohorts.A training population of 25 patients with HBV-induced LC, 20 patients with HCC, and 25 closely matched-matched healthy men, was studied. RESULTS: Two biomarkers with M_r 7 772 and 3 933 weredetected in sera of non -cirrhotic cohorts, but not in patients with HBV-induced LC. A sensitivity of 80% for all LC patients, a specificity of 81.8% for all non-cirrhotic cohorts and apositive predictive value of 75% for the study populationwere obtained .CONCLUSION: These two serum biomarkers for HBV-induced LC might be used for diagnosis and assessment of diisease progression.