论文部分内容阅读
目的比较老年与青年早期胃癌(EGC)淋巴结转移的危险因素。方法对经手术治疗的268例老年及130例青年早期胃癌患者的临床病理特征与淋巴结转移的相关性进行回顾性分析。结果青年组较老年组更易发生淋巴结转移(P=0.029),老年早期胃癌淋巴结转移与溃疡情况(P=0.014)、肿瘤大小(P=0.034)、浸润深度(P=0.004)及脉管癌栓(P<0.001)相关,合并有溃疡(P=0.042)、肿瘤浸润至黏膜下层(P=0.019)及有脉管癌栓(P=0.006)是老年EGC淋巴结转移的独立性危险因素;青年EGC淋巴结转移与性别(P=0.013)、分化程度(P=0.021)、浸润深度(P=0.011)及脉管癌栓(P<0.001)相关,女性(P=0.039)、低分化(P=0.048)、肿瘤浸润至黏膜下层(P=0.032)及有脉管癌栓(P=0.012)是青年EGC淋巴结转移的独立性危险因素。结论浸润至黏膜下层及有脉管癌栓是两组患者共同的高危因素,合并有溃疡是老年组的高危因素,女性、低分化是青年组的高危因素。
Objective To compare the risk factors of lymph node metastasis in the elderly with early gastric cancer (EGC). Methods Retrospective analysis was performed on the correlation between clinicopathological features and lymph node metastasis in 268 elderly patients with early-stage and 130 early-stage patients with gastric cancer. Results The incidence of lymph node metastasis (P = 0.029), lymph node metastasis and ulceration (P = 0.014), tumor size (P = 0.034), depth of invasion (P = 0.004) (P = 0.06), vascular invasion (P = 0.019) and vascular tumor thrombus (P = 0.006) were associated with lymph node metastasis in elderly patients with EGC (P <0.001) Lymph node metastasis was associated with gender (P = 0.013), differentiation (P = 0.021), depth of invasion (P = 0.011) and vascular tumor thrombus (P <0.001) ), Tumor invasion to the submucosa (P = 0.032) and vascular embolism (P = 0.012) were independent risk factors for lymph node metastasis in young patients with EGC. Conclusion Infiltration into the submucosa and vascular thrombosis is a common risk factor in both groups. Combined with ulcer is a risk factor for the elderly group. Female, poorly differentiated are the risk factors for the young group.