TOTAL SYNTHESIS OF CRYSTALLINE BOVINE INSULIN

• 作 者: 龚嶽亭 杜雨苍 黄惟德 陈常庆 葛麟俊 胡世全 蔣荣庆 朱尚权 钮经义 徐杰诚 张伟君 陈玲玲 李鸿绪 汪猷 陆德培 季爱雪 李崇熙 施溥涛 叶蕴华 湯卡罗 邢其毅
• 机 构: Institute of Biochemistry,Academia Sinica,Institute of Organic Chemistry,Academia Sinica,Department
• 出 处: 生命科学
• 发表日期: 2015年06期
• 关键词: communicate crystalline Sanger traces Dixon preliminary sheep elucidated concern

We should like to communicate,as a result of our combined efforts for the past five years,this preliminary report on the total synthesis of crystalline bovine insulin,the structure of which was first elucidated by Sanger and coworkers[1]ten years ago.A number of papers on the synthetic work concerning insulin has been published during the past two years.Katsoyannis and coworkers[2,3].synthesized both the A and B chains of sheep insulin and,by combining them together according to the procedure of Dixon and Wardlow[4],observed only traces of insulin activity.Zahn,Meienhofer and co-

We should like to communicate, as a result of our combined efforts for the past five years, this preliminary report on the total synthesis of crystalline bovine insulin, the structure of which was first elucidated by Sanger and coworkers [1] ten years ago.A number of papers on the synthetic work concerning insulin has been published during the past two years. Katsoyannis and coworkers [2,3] .synthesized both the A and B chains of sheep insulin and by combining them together according to the procedure of Dixon and Wardlow [4], observed only traces of insulin activity. Zahn, Meienhofer and co-