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背景:糖尿病能引起中枢神经病变,中潜伏期听觉电反应(auditorymiddlelatencyresponse,MLR)在糖尿病时的动态变化研究至今尚不十分清楚。目的:研究MLR在糖尿病中的变化,探讨MLR在早期诊断糖尿病中枢神经病变中的作用。设计:用完全随机法,采用实验对照方式,进行纵向观察研究。地点和材料:在暨南大学医学院生理研究室进行实验。用24只实验性糖尿病大鼠进行研究。方法:应用链脲佐菌素腹腔注射法,建立实验性糖尿病动物模型。在成模前后按时间顺序动态观测血糖、MLR的变化。主要观察指标:MLR的波峰潜伏期(peaklatency,PL)、波峰间潜伏期(interpeaklatency,IPL)。结果:建模后4周实验性糖尿病组MLR的PL(ms)各波延长犤P0(7.19±0.97)、Na(11.90±1.53)、Pa(18.77±1.45)、Nb(32.86±3.12)、Pb(50.32±1.68)犦(P<0.05)。6周后出现MLR各波PL、Pa-Pb的IPL犤(31.10±1.59)ms犦延长(P<0.01)。8周后MLR各波PL、P0-Pa犤(13.57±1.71)ms犦,Pa-Pb犤(35.17±2.81)ms犦IPL均延长(P<0.05或P<0.01)。糖尿病组血糖与MLR的PL,IPL各波变化之间无相关,糖尿病组病程与MLRNa,Nb,Pb波PL变化呈正相关。结论:糖尿病早期MLR出现PL和IPL延长,该变化与病程进展有相关关系,MLR是早期诊断糖尿病中枢神经病变的客观灵敏指标。
BACKGROUND: Diabetes mellitus can cause central neuropathy. The study on the dynamic changes of auditory middlesltency response (MLR) in diabetes is not yet clear. Objective: To investigate the changes of MLR in diabetes mellitus, and to explore the role of MLR in the early diagnosis of diabetic central neuropathy. Design: Using a completely random method, using experimental control methods, longitudinal observation and study. Location and Materials: Experiments in the Physiology Laboratory, Jinan University Medical College. Twenty-four experimental diabetic rats were studied. Methods: Using streptozotocin intraperitoneal injection, an experimental diabetic animal model was established. Changes in blood glucose and MLR were observed dynamically in chronological order before and after modeling. MAIN OUTCOME MEASURES: Peak latency (PL), interpeaklatency (IPL) of MLR. Results: The PL (ms) wave length of MLR in experimental diabetic group at 4 weeks after the model was prolonged by 犤 P0 (7.19 ± 0.97), Na (11.90 ± 1.53), Pa (18.77 ± 1.45), Nb (32.86 ± 3.12) (50.32 ± 1.68) 犦 (P <0.05). After 6 weeks, IPL Pa (31.10 ± 1.59) ms 犦 of MLR wave PL and Pa-Pb were prolonged (P <0.01). After 8 weeks, the IPLs of PL, P0-Pa 犤 (13.57 ± 1.71) ms and Pa-Pb 犤 (35.17 ± 2.81) ms ML of MLR were all prolonged (P <0.05 or P <0.01). No correlation was found between the blood glucose of diabetic patients and the changes of PL and IPL of MLR. The duration of diabetes mellitus was positively correlated with the changes of PL in MLRNa, Nb and Pb. CONCLUSION: The prolongation of PL and IPL in MLR during the early stage of diabetes mellitus is associated with the progression of the disease. MLR is an objective and sensitive indicator of early diagnosis of central nervous system disease of diabetes mellitus.