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转录因子-κB(NF-κB)是一类广泛存在的、调控着多种基因转录的重要转录调节因子。NF-κB的不适当表达和激活与各种疾病的发生密切相关。因此,以NF-κB为治疗靶点的药物研究可能为预防和治疗这些疾病提供新思路。本文就NF-κB信号通路与肝纤维化发生、发展及其与肝星形细胞(HSCs)之间关系的研究进展做一综述。
Transcription factor-κB (NF-κB) is a kind of ubiquitous transcription factor that regulates the transcription of many genes. Inappropriate expression and activation of NF-κB are closely related to the occurrence of various diseases. Therefore, drug research targeting NF-κB may provide new ideas for the prevention and treatment of these diseases. This review summarizes the progress of the development of NF-κB signaling pathway and hepatic fibrosis and its relationship with hepatic stellate cells (HSCs).