论文部分内容阅读
文献报告有应用砜类药物后引起的一些副作用,尤其是血液学和皮肤病学方面,然也有关于肝炎、肾病综合征、精神和周围神经病变。作者报告了一例男性60岁,1947年诊断为典型疱疹样皮炎,1948～1956年每天服1～2次磺胺吡啶,以后发生疲劳、虚弱、耳呜和唇青紫,即服醛砜钠(Aldesulphone Sodium),0.666—1.3克/天,情况很快改善。1968年趾、指端发生麻木和刺痛,逐渐向近端扩散,换用氨苯砜100～125毫克/天,感觉异常更为强烈,并扩散到膝、肘,伴冷的感觉,唇青紫,并变成易激怒,情绪不稳定。1972年停用
The literature reports some of the side effects caused by the use of sulfone drugs, especially in hematology and dermatology, but also on hepatitis, nephrotic syndrome, mental and peripheral neuropathy. The authors report a case of male 60 years old, diagnosed as herpes dermatitis in 1947, sulfapyridine 1 to 2 times daily from 1948 to 1956, followed by fatigue, weakness, tinnitus and lip cyanosis, ie Aldesulphone Sodium ), 0.666-1.3 g / day, the situation soon improved. 1968 Toe, finger numbness and tingling, and gradually spread to the proximal, with dapsone 100 ~ 125 mg / day, the feeling more abnormal and spread to the knee, elbows, with cold feeling, lip blue , And become irritable and emotionally unstable. Disabled in 1972