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目的探讨小剂量美托洛尔治疗慢性心力衰竭(CHF)的疗效及安全性。方法将36例CHF患者随机分为两组,对照组常规给予抗心衰治疗,包括强心剂、利尿剂、血管紧张素转换酶抑制剂(ACEI);治疗组加服小剂量美托洛尔,随访时间均为2年。结果疗程结束时,治疗组心胸比率与治疗前和对照组比较均呈明显缩小(P<0.05);治疗组和对照组左室射血分数(LVEF)与治疗前相比均明显增加(P<0.05)。结论小剂量美托洛尔长期治疗CHF有效、安全。
Objective To investigate the efficacy and safety of low-dose metoprolol in the treatment of chronic heart failure (CHF). Methods Thirty-six CHF patients were randomly divided into two groups. The control group was given routine anti-heart failure treatment, including cardiotonics, diuretics and angiotensin converting enzyme inhibitor (ACEI). The patients in the treatment group received low dose metoprolol, Both time is 2 years. Results At the end of treatment, the ratio of cardiothoracic to the control group was significantly reduced (P <0.05), and the LVEF of the treatment group and the control group were significantly increased compared with those before treatment (P < 0.05). Conclusion Low-dose metoprolol long-term treatment of CHF effective and safe.