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目的探讨生存素(survivin)在胃癌组织中的表达以及研究与患者年龄、病理分型、分化程度、TNM分期及淋巴结转移的关系。方法采用免疫组化SP法检测56例胃癌组织和38例正常胃黏膜组织中生存素的表达。结果生存素在胃癌组织中的阳性表达率为57.1%,在正常胃黏膜组织中无阳性表达,两组比较,差异具有的统计学意义(P<0.01)。生存素在胃癌组织中的表达与患者的年龄、肿瘤大小等因素无关(P>0.05),生存素在胃癌组织中的表达与肿瘤的分化程度、TNM临床分期及有无淋巴结转移等因素相关(P<0.05)。结论生存素在胃癌组织中表达明显增高,在胃癌的发生和进展过程中起到重要的作用,生存素的检测对于胃癌的诊断、恶性程度及预后的判断具有重要的指导意义。
Objective To investigate the expression of survivin in gastric cancer and its relationship with age, pathological type, differentiation degree, TNM stage and lymph node metastasis. Methods Immunohistochemical SP method was used to detect the expression of survivin in 56 cases of gastric carcinoma and 38 cases of normal gastric mucosa. Results The positive expression rate of survivin in gastric cancer was 57.1%, but not in normal gastric mucosa. The differences between the two groups were statistically significant (P <0.01). The expression of survivin in gastric cancer tissues was not related to the age, tumor size and other factors (P> 0.05). The expression of survivin in gastric cancer was related to the tumor differentiation, TNM clinical stage and lymph node metastasis P <0.05). Conclusion The expression of survivin in gastric cancer tissues is significantly increased, which plays an important role in the occurrence and progression of gastric cancer. The detection of survivin plays an important guiding role in the diagnosis, malignancy and prognosis of gastric cancer.