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本文报道口服乙胺碘呋酮诱发多形性室性心动过速(polymorphous ventricular tachycardia,PVT)5例。年龄46～81岁,均为器质性心脏病患者。口服乙胺碘呋酮治疗室性心律失常者3例、房颤者1例和心绞痛1例,其中3例剂量为200mg/d,1例400mg/d,1例800mg/d。最早1例发生PVT是在服药后第10天,其余4例发生在用药3周后,出现PVT时均伴有眩晕或昏厥,且下传之窦性QT间期明显延长,3例为600msec,而580和680msec各1例。2例入院时有低血钾,虽立即纠正低血钾,但仍不能终止PVT。5例患者PVT持续时间均很长,经停药并常
This article reports the oral amiodarone induced polymorphous ventricular tachycardia (PVT) in 5 cases. Age 46 to 81 years old, are organic heart disease patients. Three patients were treated with oral amiodarone for ventricular arrhythmias, one patient was atrial fibrillation and one patient was angina pectoris. Three of them were given a dose of 200 mg / d, one was 400 mg / d and the other was 800 mg / d. The first PVT occurred in the first 10 days after taking the medication, and the remaining 4 occurred in 3 weeks after the medication. All cases were accompanied by dizziness or fainting when there was PVT. The sinus QT interval was significantly prolonged in 3 cases, While 580 and 680 msec each in 1 case. 2 patients had hypokalemia on admission, although hypokalemia was corrected immediately, but still could not stop PVT. 5 patients with PVT duration are very long, the withdrawal and often