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1977年Boucher等氏报告鼠体内各种组织中含有一种新的血管紧张素Ⅱ生成酶,称之为紧张肽(tonin)。此酶与肾素和转换酶完全不同,它能切断苯~8～组~9键,因而既能使血管紧张素Ⅰ转变成血管紧张素Ⅱ,又能直接使血管紧张素元转变成血管紧张素Ⅱ。这就构成了血管紧张素元—[紧张肽]—血管紧张素Ⅱ系统,此系统不同于经典途径,即:血管紧张素元—[肾素]—血管紧张素Ⅰ—[转换酶]—血管紧张素Ⅱ系统。
In 1977, Boucher et al. Reported that various tissues in the rat contain a novel angiotensin II-producing enzyme called tonin. This enzyme and renin and conversion enzyme completely different, it can cut benzene ~ 8 ~ 9 bond, which can not only make angiotensin Ⅰ into angiotensin Ⅱ, but also directly to the angiotensin element into vascular tension Prime Ⅱ. This constitutes the angiotensin element - [tension peptide] - angiotensin II system, which is distinct from the classical pathways of angiotensin- [renin] - angiotensin I- [converting enzyme] - blood vessels Tension system.