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目的:分析研究表皮生长因子(EGFR)在中国结直肠癌患者癌组织中的表达与淋巴结转移及肝脏转移的相关性。方法:利用万方、维普、CNKI、PubMed、Web of Science和EMBASE数据库,以“结直肠癌、结直肠肿瘤、大肠癌、EG-FR、表皮生长因子受体”为关键词,检索2000-2012年公开发表的关于结直肠癌患者癌组织中EGFR的表达与淋巴结转移及肝脏转移关系的文献,对文献进行筛选和评价,符合标准的文献用Revman 5.0软件进行Meta分析。结果:EG-FR表达与淋巴结转移相关文献入选17篇,共2 092例患者,淋巴结转移患者1 040例,523例EGFR阳性,无淋巴结转移者1 052例,327例EGFR阳性,异质性检验提示各研究结果间存在异质性(χ2=43.48,P=0.000 2,I2=63%),采用随机效应模型进行合并OR=3.17,95%CI=2.19～4.60,合并效应量的检验结果显示z=6.08,差异有统计学意义(P<0.01),提示有淋巴结转移的患者,癌组织中EGFR的表达高于无淋巴结转移者;EGFR表达与肝转移相关文献入选4篇,共385例患者,其中肝转移患者154例,90例EGFR阳性,无肝转移者231例,65例EGFR阳性,异质性检验存在异质性(χ2=14.44,P=0.002,I2=79%),采用随机效应模型进行合并,OR=3.99,95%CI=1.04～15.36,合并效应量的检验结果显示z=2.01,差异有统计学意义(P=0.04),提示有肝转移的患者,癌组织中EGFR的表达显著高于无肝转移者。结论:在中国结直肠癌患者中,发生淋巴结转移和肝转移的患者癌组织中EGFR的表达明显升高,EGFR检测对筛选高危转移者具有重要意义。
Objective: To study the relationship between the expression of epidermal growth factor (EGFR) and the lymph node metastasis and liver metastasis in Chinese patients with colorectal cancer. Methods: The key words of colorectal cancer, colorectal cancer, colorectal cancer, EG-FR and epidermal growth factor receptor were searched by Wanfang, VIP, CNKI, PubMed, Web of Science and EMBASE database. - Published in 2012 on the expression of EGFR in cancerous tissues of patients with colorectal cancer and lymph node metastasis and liver metastasis of the literature, the literature screening and evaluation of standard literature using Revman 5.0 software for meta-analysis. Results: There were 17 articles about the expression of EG-FR and lymph node metastasis in a total of 2 092 cases, 1 040 cases of lymph node metastasis, 523 cases of EGFR positive, 1052 cases without lymph node metastasis, 327 cases of EGFR positive and heterogeneous test (Χ2 = 43.48, P = 0.0002, I2 = 63%). The OR of the random effects model was 3.17, and the 95% CI was 2.19 to 4.60. The test results of the combined effect showed that there was no significant difference z = 6.08, the difference was statistically significant (P <0.01), suggesting that patients with lymph node metastasis, the expression of EGFR in cancer tissue was higher than those without lymph node metastasis; EGFR expression and liver metastasis related literature selected 4, a total of 385 patients Among them, 154 were liver metastases, 90 were EGFR positive, 231 were liver metastases, and 65 were EGFR positive. Heterogeneity was heterogeneous (χ2 = 14.44, P = 0.002, I2 = 79% OR = 3.99, 95% CI = 1.04 ~ 15.36, the test results of the combined effect showed that z = 2.01, the difference was statistically significant (P = 0.04), suggesting that liver metastases in patients with cancer, EGFR The expression was significantly higher than those without liver metastasis. Conclusion: In Chinese patients with colorectal cancer, the expression of EGFR is significantly increased in patients with lymph node metastasis and liver metastasis. The detection of EGFR is of great significance in screening high-risk metastasis.