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选用标化成年雄性Wistar大鼠、以放射免疫测定法（RIA），研究了大鼠由平原引入高海拔环境后，在24小时急性司服期，垂体及各脑区内β－内啡肪样免疫活性物质（β－EPLI）的含量变化。结果表明，大鼠引入高海拔环境后脑内β－EP含量发生明显的动态变化。高海拔实验组与平原对照组相比，垂体内β－EP含量降低非常显著（P＜0．01）。纹状体、下丘脑、丘脑、桥延、海马、皮层内β－EP含量增加非常显著（P＜0．01）。中脑内β－EP含量虽然也增加，统计学处理无显著性意义（P＞0．05）。据此推测：大鼠急进高海拔低氧环境后垂体β－EP的分泌与释放受到影响。提示，脑内β－EP参与低氧的应激反应过程，可能作为神经递质和调质，通过神经──内分泌环路在应激反应中起介导作用，β－EP可能为中枢神经系统内调节应激反应的主要应激激素之一。
Normal adult male Wistar rats were selected and radioimmunoassay (RIA) was used to study the effect of β-endomorphin in the pituitary and brain regions Changes in the content of immunologically active substances (β-EPLI). The results showed that the rat brain after the introduction of high-altitude environment, the content of β-EP significant dynamic changes. Compared with the control group, the decrease of β-EP in the pituitary was significant (P <0.01) in high altitude experimental group. The content of β-EP in striatum, hypothalamus, thalamus, bridging, hippocampus and cortex increased significantly (P <0.01). Although in the brain β-EP content also increased, no statistically significant statistical significance (P> 0.05). According to the above results, the secretion and release of pituitary β-EP in rats after acute high altitude hypoxia were affected. It is suggested that β-EP involved in the process of hypoxia may play a neurotransmitter and refolding role in the stress response through the nervous-endocrine loop. Β-EP may be the central nervous system One of the major stress hormones that regulate stress response.