论文部分内容阅读
目的：观察急性重复缺氧动物产生间歇性低氧适应及对脑组织细胞的保护作用。结果：一次急性缺氧时血液和脑组织中的ＧＳＨｐｘ活性明显下降（Ｐ＜００１），其中脑组织中的ＧＳＨｐｘ活性在急性重复缺氧时被激活（Ｐ＜００５）。脑组织抗氧化能力增强。同时脑组织的Ｇｌｓ含量明显下降（Ｐ＜００１）。结论：Ｇｌｓ和ＧＳＨｐｘ有抗自由基活性。急性重复性缺氧Ｇｌｓ下降同时ＮＥ下降，不同于持续性低氧表现，推测脑细胞β受体－腺苷酸环化酶系统在急性重复缺氧时未受严重伤害。
Objective: To observe the effect of intermittent hypoxia adaptation and protective effect on brain cells in acute repeated hypoxia animals. Results: The activity of GSHpx in blood and brain tissue was significantly decreased in an acute hypoxia (P <001). GSHpx activity in brain tissue was activated in acute repeated hypoxia (P <005). Brain antioxidant capacity increased. At the same time, the content of Gls in brain decreased significantly (P <001). Conclusion: Gls and GSHpx have anti-free radical activity. Acute repetitive hypoxia decreased Gls at the same time NE decreased, unlike persistent hypoxia, presumed that the brain cell beta-adenylate cyclase system was not seriously injured in acute repeated hypoxia.