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目的检测慢性阻塞性肺病（ＣＯＰＤ）患者运动耐力与运动时通气与气体交换指标的变化，探讨其运动耐力及呼吸功能损害的机制。方法非急性发作期ＣＯＰＤ 患者行坐式脚踏功率车运动至次极量水平，连续检测其通气与气体交换指标，并与健康对照组比较。结果 ＣＯＰＤ组最大运动负荷（ＷＲ）减低，最大耗氧量（ＶＯ２）、最大潮气量（ＶＴ）均减低；最大通气量（ＶＥ）与对照组无差别，但通气储备量（ＢＲ）降低；两组运动中死腔量与潮气量比值（ＶＤ／ＶＴ）均显著降低，但 ＣＯＰＤ组的降低幅度较小。结论 ＣＯＰＤ 患者运动耐力下降，其主要因素可能是 ＶＴ的增加受限所致的通气功能损害； ＶＤ／ＶＴ比值较高所致的通气 效率降低也可能有一定影响。
Objective To detect the changes of exercise tolerance and ventilation and gas exchange in patients with chronic obstructive pulmonary disease (COPD), and to explore the mechanism of exercise endurance and respiratory dysfunction. Methods The patients with COPD undergoing non-acute exacerbation exercising to the submaximactic level were continuously ventilated with gas exchange indicators and compared with the healthy control group. Results The maximal exercise load (WR) in COPD group decreased and the maximal oxygen consumption (VO2) and maximal tidal volume (VT) decreased. The maximal ventilation (VE) had no difference with the control group but the ventilation reserve (BR) The ratio of dead space to tidal volume (VD / VT) in group exercise decreased significantly, but the decrease in COPD group was smaller. Conclusion The decline of exercise tolerance in patients with COPD may be caused by the impaired ventilatory function due to the limited increase of VT. The decreased ventilatory efficiency may also be affected by the high VD / VT ratio.