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过氧化物酶体增殖物激活受体(PPARs)作为一类核转录因子,能与其特异性配体结合,进而在转录水平上调节多种基因的表达。近年来研究发现,PPARs的辅调节因子,包括辅激活因子和辅抑制因子,能够通过不同的机制促进或抑制PPARs的转录活性,调节其目的基因的表达。并且还是很多细胞内信号通路和翻译后修饰作用的对象,在肾脏疾病的进展中发挥重要重要。选择不同的辅调节因子的激活剂或抑制剂来调节相关基因的转录活性,将会成为治疗一些肾脏疾病如肾小球硬化、肾小球肾炎、糖尿病肾病及肾小管间质疾病的新的治疗手段和方法。
Peroxisome proliferator-activated receptors (PPARs), as a class of nuclear transcription factors, can bind with their specific ligands and then regulate the expression of multiple genes at the transcriptional level. In recent years, it has been found that co-regulators of PPARs, including coactivators and co-repressors, can promote or inhibit the transcriptional activity of PPARs through different mechanisms and regulate the expression of their target genes. And is also a target of many intracellular signaling pathways and posttranslational modifications that play an important role in the progression of kidney disease. Choosing different co-regulators of activators or inhibitors to regulate the transcriptional activity of related genes will be a new treatment for several kidney diseases such as glomerulosclerosis, glomerulonephritis, diabetic nephropathy and tubulointerstitial disease Means and methods.