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肺癌是常见的恶性肿瘤,非小细胞肺癌(NSCLC)占原发性肺癌的80%,相当一部分患者在原发肿瘤切除后出现肿瘤复发。即使是临床上通过影像学检查和手术的常规病理检查未发现有转移而诊断为早期的NSCLC患者,也有可能存在隐匿性转移,谓之微转移。微转移是行根治术后早期NSCLC患者死亡的主要原因。如何发现临床分期中尚属早期NSCLC患者的微转移,进而调整治疗策略和正确评估预后是近年来肺癌研究的热点。
Lung cancer is a common malignancy. Non-small cell lung cancer (NSCLC) accounts for 80% of primary lung cancer. A significant proportion of patients have tumor recurrence after primary tumor resection. Even in patients with NSCLC diagnosed as early stage who have not been found by conventional pathological examination of imaging and surgery clinically, there is a possibility of occult metastasis, called micrometastasis. Micrometastasis is the leading cause of death in early-stage NSCLC after radical operation. How to find the micrometastases in patients with early-stage NSCLC in clinical staging, and then adjust the treatment strategy and correct assessment of prognosis are the hot spots of lung cancer research in recent years.