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缺血心肌恢复其血流灌注可引起严重的节律紊乱,即再灌注性心律失常(reperfusion arrhythmias)。这一病理过程,临床上常发生在一过性冠脉痉挛、血栓溶解或冠脉搭桥术之后,不仅是冠心病患者猝死的主要原因之一,也是影响心肌梗塞再通疗法疗效的严重并发症,因而探讨其发生机理及有效的防治措施有十分重要的临床意义。本文以室颤阈(VFT)作为反映心脏易损性的指标,观察了阻断家兔冠脉左室支造成急性心肌缺血40分钟后再灌注40分钟VFT的动态变化及氧自由基清除剂超氧化物歧化酶(SOD)对再灌注时VFT的影响。
Ischemic myocardium regaining its blood perfusion can cause severe circadian rhythms, namely reperfusion arrhythmias. This pathological process, clinically often occurs in patients with transient coronary spasm, thrombolysis or coronary artery bypass grafting, is not only one of the major causes of sudden death in patients with coronary heart disease, but also a serious complication affecting the efficacy of recanalization of myocardial infarction , So to explore its mechanism of occurrence and effective prevention and treatment measures have very important clinical significance. In this paper, ventricular fibrillation threshold (VFT) as an index of vulnerability to the heart to observe the rabbit coronary artery left ventricular branches caused by acute myocardial ischemia 40 minutes after reperfusion 40 minutes VFT dynamic changes and oxygen free radical scavenger Effect of Superoxide Dismutase (SOD) on VFT during Reperfusion.