Determination of lercanidipine in human plasma by an improved UPLC-MS/MS method for a bioequivalence

• 作 者: Darshan V. Chaudhary Daxesh R
• 机 构: DepartmentofChemistry,LaboratoryofMetabolism,DepartmentofChemistry
• 出 处: 药物分析学报：英文版
• 发表日期: 2016年2期
• 关键词: 生物等效性 人血浆 地平 测定 超高效液相色谱 盐酸 MS/MS 串联质谱 LercanidipineUPLC-MS/MSBioequivalenceSolid
• 基金项目: One of the authors, Darshan V. Chaudhary, would like to thank UGC-BSR （F 4-1/2009 （BSR）/7-74/2007）, New Delhi, for research fellowship, F 4-1/2009 （BSR）/7-74/2007, and Department of Chemistry, Gujarat

An improved and reliable ultra-performance liquid chromatography/tandem mass spectrometry(UPLC–MS/MS) method has been developed and validated for the determination of lercanidipine in human plasma. Plasma samples with lercanidipine-d3 as an internal stand