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复发或难治性宫颈癌的死亡率高、预后差。在放疗后复发的宫颈癌患者再次放疗疗效差,且并发症多。手术治疗只适合于放疗后中心性复发的患者,对于放疗后非中心性复发或放疗加手术后复发的患者,治疗起来非常棘手。这些患者常有输尿管梗阻,肾功能受损,而影响化疗药物的应用。化疗已普遍应用于复发及难治性宫颈癌的治疗,现就目前化疗的进展加以综述,以期寻找更佳的化疗方案,提高复发及难治性宫颈癌患者的生活质量以及存活率。
Recurrence or refractory cervical cancer mortality is high, the prognosis is poor. Cervical cancer recurrence after radiotherapy in patients with radiotherapy again poor curative effect, and complications. Surgical treatment is only suitable for patients with central recurrence after radiotherapy, for patients with non-central recurrence or radiotherapy and postoperative recurrence after radiotherapy, the treatment is very tricky. These patients often have ureteral obstruction, impaired renal function, which affects the application of chemotherapy drugs. Chemotherapy has been widely used in the treatment of recurrent and refractory cervical cancer. The current progress of chemotherapy is reviewed in order to find better chemotherapy and improve the quality of life and survival rate of patients with recurrent and refractory cervical cancer.