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苯的氨基和硝基化合物可使人类和动物引起中毒性高铁血红蛋白血症和红细胞赫恩小体。本文通过一次小剂量硝基苯经皮染毒造成2只大白兔急性轻度中毒反应后,观察其高铁血红蛋白、赫恩小体和网织红细胞的动态变化,以了解此三者的变化特点。 方法 同种雌性大白兔2只,各重2Kg,背部皮肤剪毛后,各以纯度99.5％硝基苯溶液0.5ml涂擦在背部皮肤6cm~2表面。染毒要求是造成急性轻度中毒反应模型,但动物仍保持清醒状态,能吃食物,无明显烦躁或抑制。染毒后按一定
Amino and nitro compounds of benzene can cause toxic methemoglobinemia and red blood cell hern bodies in humans and animals. This article through a small dose of nitrobenzene transdermal exposure caused acute mild poisoning reaction in two rabbits, observing its methemoglobin, Hernand and reticulocyte dynamic changes in order to understand the characteristics of these three changes. Methods Two female rabbits of the same type, each weighing 2 kg, were cut on the back of the skin, and each of them was smeared on the surface of 6 cm ~ 2 of the back skin with a purity of 99.5% nitrobenzene solution 0.5 ml. Exposure requirements are caused by acute mild toxicity response model, but animals remain sober, can eat food, no obvious irritability or inhibition. After exposure by certain