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目的 :探讨宫颈分泌物中的脱磷酸化的胰岛素样生长因子结合蛋白 -1(IGFBP -1)在胎膜早破预测中的意义。方法 :应用免疫层析法检测 60例胎膜早破孕妇宫颈阴道分泌物中脱磷酸化的IGFBP -1的含量。结果 :胎膜早破组 ,正常孕妇组IGFBP-1的阳性率分别为 98 3 %和 8 3 %两组结果相比 ,差异有统计学意义 (P <0 0 5 )。结论 :检测宫颈阴道分泌物中的IGFBP -1是诊断胎膜早破快速、准确的方法
Objective: To investigate the significance of dephosphorylated insulin-like growth factor binding protein-1 (IGFBP-1) in the prediction of premature rupture of membranes in cervical secretions. Methods: The immunostaining method was used to detect the dephosphorylated IGFBP-1 levels in cervical vaginal secretions of 60 pregnant women with premature rupture of membranes. Results: The positive rates of IGFBP-1 in premature rupture of membranes group and normal pregnant women group were 98 3% and 83%, respectively. The difference was statistically significant (P0 05). Conclusion: The detection of IGFBP-1 in cervical vaginal secretions is a rapid and accurate method for the diagnosis of premature rupture of membranes