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目的:探讨紫癜肾汤治疗儿童紫癜性肾炎的疗效。方法:选取2009年1月~2014年6月在该院住院的紫癜性肾炎(Henoch-Schonlein purpura nephritis,HSPN)患儿100例为研究对象,随机分成观察组和对照组,每组各50例。观察组接受常规西医治疗的基础上加用紫癜肾汤,对照组接受常规西医治疗。结果:观察组总有效率98.00%,高于对照组的总有效率72.00%,差异有统计学意义(P<0.01)。随访6个月,观察组复发率8.00%,低于对照组的复发率28.00%,差异有统计学意义(P<0.01)。治疗后,观察组患儿尿Ig G、α1微球蛋白、β2微球蛋白水平、CD4+/CD8+水平均低于对照组,差异均有统计学意义(P<0.05、P<0.01)。治疗后,观察组患儿CD3+、CD4+及CD8+水平均高于对照组,差异有统计学意义(P<0.01)。治疗后,观察组患儿血清IL-6、IL-18、TNF-α均低于对照组,差异均有统计学意义(P<0.01、P<0.05)。治疗后,观察组患儿血清IL-10高于对照组,差异有统计学意义(P<0.01)。结论:紫癜肾汤治疗儿童紫癜性肾炎疗效显著,可有效调节患者免疫功能,减轻患者炎症反应,改善肾组织病理损伤。
Objective: To investigate the therapeutic effect of purpuric kidney soup on purpuric nephritis in children. Methods: One hundred children with Henoch-Schonlein purpura nephritis (HSPN) hospitalized in our hospital from January 2009 to June 2014 were selected as the research object and randomly divided into observation group and control group with 50 cases in each group . Observation group received routine Western medicine treatment based on the addition of purpuric kidney soup, the control group underwent routine Western medical treatment. Results: The total effective rate in observation group was 98.00%, which was higher than that in control group (72.00%), the difference was statistically significant (P <0.01). The follow-up of 6 months showed that the recurrence rate was 8.00% in the observation group and 28.00% in the control group, with a significant difference (P <0.01). Urine Ig G, α1 microglobulin, β2 microglobulin and CD4 + / CD8 + in the observation group were lower than those in the control group after treatment. The differences were statistically significant (P <0.05, P <0.01). After treatment, the levels of CD3 +, CD4 + and CD8 + in the observation group were significantly higher than those in the control group (P <0.01). After treatment, the levels of IL-6, IL-18 and TNF-α in the observation group were significantly lower than those in the control group (P <0.01, P <0.05). After treatment, the serum IL-10 in the observation group was significantly higher than that in the control group (P <0.01). Conclusion: Purpuric Kidney Decoction has a significant therapeutic effect on purpuric nephritis in children, which can effectively regulate the immune function, alleviate the inflammatory reaction and improve the renal pathological injury.